Neuro-Mag™ Magnesium L-Threonate
90 vegetarian capsules Item Catalog Number: 01603

Half of the older people in the developed world are magnesium deficient.61 Don’t be one of them! Magnesium is needed for more than 300 biochemical reactions in the body.62 In addition to support for cardiovascular and bone health,energy metabolism and mood, researchers are now focusing intensely on magnesium’s benefits for cognitive function.Unfortunately, it is very hard for your body to maintain optimal levels of magnesium in the brain. This problem is of special concern for maturing individuals, as magnesium deficiency increases over time.

Most commercially available magnesium supplements are not readily absorbed into the nervous system. To overcome this obstacle, you can supplement with an innovative form of magnesium called Neuro-Mag™, shown to specifically target the aging brain and nervous system.

In pre-clinical models, L-threonate contained in Neuro-Mag™ boosted magnesium levels in spinal fluid by an impressive 15% compared to no increase with conventional magnesium. Even more compelling, animal models revealed improvements of 18% for short-term memory and 100% for long-term memory using theNeuro-Mag™ form of magnesium.The suggested daily dose of three Neuro-Mag™ Magnesium L-Threonate capsules provides 2,000 mg of magnesium L-threonate. While this supplies a modest 144 mg of elemental magnesium, its superiorabsorption into the bloodstream and nervous system make it a preferred supplemental choice.

N-Acetyl-L-Cysteine
600 mg, 60 vegetarian capsules Item Catalog Number: 01534

L-cysteine is a conditionally essential amino acid, one of only three sulfur-containing amino acids, the others being taurine (which can be produced from L-cysteine) and L-methionine (from which L-cysteine can be produced in the body by a multi-step process). Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine.136-138 Cysteine also helps synthesize glutathione, the body’s most important intracellular antioxidant and a vital detoxifier.139-142

N-acetyl-L-cysteine (NAC) is the acetylated form of L-cysteine that has been used to break up pulmonary and bronchial mucous.143-146 It is very efficiently absorbed and has been shown to protect cells directly and support the immune system.146-155 NAC is an antioxidant and a free radical-scavenging agent that increases intracellular glutathione at the cellular level. NAC can act as a precursor for glutathione synthesis as well as a stimulator of the cytosolic enzymes involved in glutathione regeneration.146 NAC has been shown to protect against oxidative stress-induced neuronal death in cultured granule neurons.156

References
SUPPLEMENT FACTS
Supplement Facts
Serving Size 1 vegetarian capsule
Amount Per Serving
N-acetyl-L-cysteine
600 mg
Other ingredients: vegetable cellulose (capsule), vegetable stearate, silica.
Non-GMO
Dosage and Use
Take one (1) capsule one to three times daily with or without food, or as recommended by a healthcare practitioner.
Caution
Those who supplement with NAC should drink 6 to 8 glasses of water daily in order to prevent cysteine renal stones. Cysteine renal stones are rare but do occur.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Beta-Carotene
25,000 IU 100 softgels Item Catalog Number: 00664
Vitamin A (retinol) is a yellow, fat-soluble, generic term for a large number of related compounds obtained from some carotenoids by conversion in the liver, its storage organ. Retinol (an alcohol) and retinal (an aldehyde) are often referred to as preformed vitamin A. While carotenoids are widely distributed in such foods as green and yellow vegetables, retinol is not found in any vegetable sources, but is concentrated in egg yolks and the livers of many animals. Vitamin A, either from animal sources or synthesized in our own liver, is essential for growth and reproduction, maintaining healthy vision, and supporting protein synthesis and cell differentiation.

Vitamin A and its analogs have shown the ability to help maintain proper DNA function.1-3 One study, however, has shown that for certain lifestyles (e.g., smokers) supplemental intake of too much beta-carotene in the absence of other carotenoids and antioxidants (such as at least 400 IU/day of vitamin E) may be harmful.4

Beta-carotene is the most potent precursor to vitamin A, but its conversion to vitamin A in the body is limited by a feedback system. It is an important antioxidant in its own right and one that can only build up to toxic levels in rare circumstances. Beta-carotene helps support immune health by enhancing the function of the thymus gland.5,6

References
1. Cell Mol Life Sci. 2004 Jun;61(12):1475-84.
2. Curr Cancer Drug Targets. 2004 May;4(3):285-98.
3. Nutr Cancer. 2002;42(1):117-24.
4. Biochim Biophys Acta. 2002 Feb 20;1574(1):85-92.1. JAMA. 2003 Jul 23;290(4):476-85.
5. Eksp Klin Farmakol. 1993 Jan-Feb;56(1):49-51.
6. Vopr Med Khim. 1992 Nov-Dec;38(6):31-3.

Two-Per-Day Capsules
Highest Potency Multivitamin On The Mark

Life Extension’s Two Per Day multivitamins have the highest nutritional potencies of any science-based multivitamin formula that can fit inside two capsules or Capsules. This gives you far more of the essential vitamins, minerals and health-promoting nutrients than typical store-bought formulas … and it does so at a very economical price. Why is this so important? While Recommended Daily Allowances (RDAs) were developed by the government, they only provide the minimal doses to protect you from deficiency. Research studies demonstrate that unless you’re taking the ideal dose of vitamins and minerals, you won’t fully receive their benefits for optimal health and well-being. Two-Per-Day now contains three potent forms of selenium (SelenoExcell®, Se-methyl-selenocysteine, and sodium selenite). Also newly included is apigenin, a powerful bioflavonoid found in many vegetables and fruits which boosts cell protection.

Benefits at a Glance: Our Formula Beats Centrum® 10 ways*

• 50 times more vitamin B1

• 12 times more vitamin B12

• 25 times more vitamin B6

• 10 times more biotin

• 10 times more selenium

• 8 times more vitamin C

• 2 times more vitamin D

• 2 times more vitamin E

• 2.7 times as much vitamin B3

• 3 times as much zinc

*Formula compared to Centrum® Silver® Adults 50+

Tillatt brukt for voksne over 18 år. Kan være helseskadelig for barn og unge under 18 år. All bruk av tilskudd foregår på eget ansvar og bør skje i samråd med lege. Om ikke er angitt er anbefalt dosering 1 oppgitt enhet (tablett, kapsle, teskje, pose, dråpe eller sprut) dag
Forbehold. Uno Vita hevder ikke at produktene vi markedsfører kan kurere sykdom.

Cran-Max® Cranberry Whole Fruit Concentrate

Cran - Max contains concentrated cranberry made from the complete cranberry using a unique process, with no added sugar. Each capsule of this product contains powerful polyphenols, organic acids and antioxidants that provide the same benefits as drinking cranberry juice cocktail minus calories. An advantage of Life Extension’s Cran-Max® is that it only requires once a day dosing.

The anatomy of the female urinary tract differs greatly from men, resulting in the need for additional nutritional support for women. A wealth of published studies indicates that cranberry polyphenols may help to support a healthy urinary tract.63-67

Cranberries have been known for decades to promote a healthy urinary tract. Clinical research demonstrates that cranberries’ proanthocyanidins are powerful antioxidants that can reduce oxidative stress.72 A double-blind comparison study confirms that Cran-Max® helps support a healthy urinary tract.73 Each Life Extension Cran-Max® capsule contains 500 mg of cranberry concentrate to promote urinary tract health.66,74-84 Each Cran-Max® capsule also contains:

The synergistic, complete spectrum activity of the entire cranberry whole fruit
A unique delivery system that protects its cranberry constituents from degradation

Antioxidants
Cran-Max® contains concentrated cranberry made from the complete cranberry using a unique, patent-pending process. No sugar is added. Each capsule of Cran-Max® contains powerful polyphenols, organic acids, and antioxidants, providing the same benefits as drinking cranberry juice cocktail, but without the calories. An advantage of Life Extension’s Cran-Max® is that it only requires once a day dosing!

References (referanser) here!

Super Absorbable Tocotrienols (60 capsules)
Life Extension's Super-Absorbable Tocotrienols softgels deliver high-quality vitamin E tocotrienols derived from red palm oil from the Elaeis guineensis tree. Because of their specific chemical structure, tocotrienols provide potent antioxidant benefits throughout the body.

• The patented SupraBio™ absorbs, on average, 250 percent better than conventional tocotrienol oil extract.
• Super Absorbable Tocotrienols Benefits
• Inhibits oxidation
• Promotes whole-body health
• Helps shield DNA and protect cellular membranes
• Promotes healthy hair growth and cell division
• Encourages healthy brain function

Magnesium Caps

500 mg, 100 vegetarian capsules

Magnesium is one of the body’s most important minerals. It is required as a cofactor in hundreds of enzymatic processes within cells.16 It helps maintain normal muscle and nerve function, keeps heart rhythm steady, promotes healthy cardiovascular function, supports a healthy immune system, and keeps bones strong. Magnesium also helps maintain blood sugar and blood pressure levels already within normal range, and it is known to be involved in energy metabolism and protein synthesis.17,18

Magnesium is a major factor in relaxing the smooth muscles within the blood vessels, thereby reducing peripheral vascular resistance and promoting a healthy cardiovascular system.19-21 Magnesium also affects circulating levels of norepinephrine and the synthesis of serotonin and nitric oxide.22-24

Magnesium positively influences the bone mineral matrix and its ability to metabolize minerals needed for repair and rebuilding.25,26 Scientific literature documents the need for a wide range of minerals, including calcium and magnesium, that are vital to maintaining strong, healthy bones.

Moreover, there is strong evidence that dietary magnesium intake and supplementation improves the metabolic profile.86-88 Magnesium has been shown to beneficially impact insulin resistance, serum lipid profiles, inflammation, endothelial function, oxidative stress and platelet aggregability.89

Since magnesium is so inexpensive, everyone should consider supplementing with at least 500 mg of magnesium daily. Magnesium Caps provides one of the highest concentrations of elemental magnesium per capsule available on the market.

References

Liquid Emulsified Vitamin D3 

Vitamin D3 can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight. But, due to the winter season, weather conditions, and sun block, the body’s ability to produce optimal vitamin D levels may be inhibited.87 These factors point to the value of taking a daily vitamin D supplement.

Vitamin D has long provided significant support for healthy bone density.88-94 However, scientists have also validated the critical role that vitamin D plays in regulating healthy cell division and differentiation, and its profound effects on human immunity.95-101 These findings link a deficiency of vitamin D to a host of common age-related problems.

The current RDA for vitamin D is only 600 IU which has resulted in startling evidence of a widespread deficiency for this vitamin. Most experts in the field now recommend intakes between 1,000 - 10,000 IU for adults to achieve a serum 25(OH)D level above those indicative of vitamin D deficient levels, at approximately 80 nmol/L or 32 ng/mL.

Life Extension suggests that healthy adults supplement each day with 5000-8000 IU of vitamin D with the objective of achieving an optimal 25-hydroxy vitamin D blood level between 50-80 ng/mL. A vitamin D blood test can help you determine the additional amount of vitamin D you may need to supplement to achieve an optimal level.

ADRENAL ENERGY FORMULA

Adrenal Energy Formula
120 vegetarian capsules
Item Catalog Number: 01630

When properly supported, the mechanism known as homeostasis enables the body to maintain its normal balance during stress, helping us to remain energized and focused.

Increasingly overwhelmed by stress, however, our bodies seldom get a chance to restore our natural equilibrium.

The result is that an estimated 75%–90% of visits to primary care physicians are now related to the effects of stress.15

Even more alarming is a recently published study16 linking stress with shorter telomeres (the caps on the ends of chromosomes), which is associated with accelerated aging!

Stress disrupts multiple biochemical pathways, including cortisol production, the hypothalamus-pituitary-adrenal (HPA) axis, pro-inflammatory enzyme production and neurotransmitter production. A pre-clinical study has shown that stress also inhibits neural plasticity (the growth of new connections between neurons in the brain)!17

Fortunately, Life Extension® has created a state-of-the-art formulation of botanical adaptogens, shown to modulate a broad range of factors to help relieve the effects of stress.

Adrenal Energy Formula combines four known stress-modulating extracts—Holy Basil, Cordyceps, Bacopa, and Ashwagandha—each scientifically validated to support homeostasis, even on the most stressful days.

Each of these extracts modulates a different set of stress related changes in the body’s chemistry.18-30 Combined, they may complement each other to provide complete adaptogenic stress defense!

For those who are seeking protection from the effects of stress, Adrenal Energy Formula™ is a broad-spectrum, potent, and safe formulation for maintaining healthy energy and vitality!

Supplement Facts
Serving Size 2 vegetarian capsules
Servings Per Container 60
Amount Per Serving

OciBest® Holy Basil (Ocimum tenuiflorum) extract 10:1 (whole plant) [std. to 2.5% triterpene acids (15 mg)] 600 mg Proprietary Blend: 516 mg
Sensoril® Ashwagandha (Withania somnifera) extract 5:1 (root and leaves) [std. to 8% withanolide glycoside conjugates and 32% oligosaccharides]
Cordyceps (Paecilomyces hepiali) extract 8:1 (mycelia) [std. to 7% cordycepic acid] BaCognize® Ultra (Bacopa monnieri) extract 25:1 (whole herb) [std. to 25% bacopa glycosides]

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, maltodextrin, ascorbyl palmitate, silica.
BACOGNIZE® ULTRA is a registered trademark of Verdure Sciences, Inc.
OciBest® is a registered trademark of Natural Remedies Private Limited.
Sensoril® is protected under US Patent Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc.

Dosage and Use
Take two (2) capsules twice daily with or without food, or as recommended by a healthcare practitioner.

Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Life Extension Mix Caps (360)
The many nutrients in Life Extension Mix™ Capsules can give you full daily coverage of the nutrients that your body requires to function properly every day.

Life Extension Mix™ is an advanced, high-potency vitamin, mineral, fruit and vegetable supplement that provides all the daily nutrients your body needs to form the cornerstone of a comprehensive health maintenance program. We’ve combined nature’s most important nutrients into one product, eliminating the need to take dozens of separate supplements.

This state-of-the-art formula packed with potent forms of vitamins, minerals and more, includes a highly bioavailable form of quercetin.
Life Extension Mix™ Capsules Benefits
Provides a full spectrum of essential nutrients for whole-body health & longevity
Promotes healthy DNA & cellular proliferation
Supports metabolic & cardiovascular health
Helps inhibit oxidative stress & supports a healthy inflammatory response
Backed by Research
Life Extension Mix™ is a state-of-the-art multi-nutrient formula for advanced supplement users. It contains vegetable, fruit and botanical extracts, as well as high-potency doses of healthy vitamins and minerals. Discover the extensive benefits of Life Extension Mix™!

Product Details Every daily dose of Life Extension Mix™ gives you an extensive array of nutrients.

Bioactive quercetin phytosome
Life Extension Mix™ contains 5 mg of quercetin that has been integrated into a phytosome, a phospholipid sphere that encases a botanical compound, aiding in its absorption and making it more bioavailable; this quercetin phytosome is up to 50 times more bioavailable than standard quercetin.1 Quercetin promotes healthy immune function and supports cardiovascular and endothelial health.2,3 It also helps inhibit oxidative and inflammatory factors to support immune health.4,5

Delphinidins
Found in dark red fruits, delphinidins are potent anthocyanin compounds that activate the production of nitric oxide, supporting endothelial health, promoting vascular relaxation and helping maintain already-healthy blood pressure.6-9 Anthocyanins can also help inhibit inflammatory factors and glycation to support immune health, protect DNA structure and help maintain healthy blood sugar levels already within the normal range.10-15 Our formula features delphinidins from maqui berry extract.16

Pyridoxal 5'-phosphate
Glycation is a normal part of the aging process that can affect your health.17-20 To help inhibit glycation, each daily dose of Life Extension Mix™ provides 100 mg of pyridoxal 5'-phosphate, a metabolically active B6 that has been shown to help inhibit glycation reactions.21,22

Standardized pomegranate extract
Our pomegranate extract is standardized to provide punicalagins specific to this fruit. These potent polyphenols have a wide range of health benefits: They help maintain blood pressure already within the normal range, promote healthy endothelial function, inhibit oxidative stress, positively influence a host of markers for metabolic and cardiovascular health and promote a healthy inflammatory response.23-34

Blueberry extracts
Life Extension Mix™ features a wild blueberry extract packed with active blueberry constituents. Blueberry anthocyanins help inhibit free radicals, while blueberry's other active constituents promote healthy lipid and glucose levels for those already within the normal range.35,36 Even more exciting: these blueberry constituents may help protect DNA structure and promote healthy cellular proliferation.37-39 In clinical studies, blueberries have been shown to inhibit inflammatory factors and have antioxidant benefits to support a healthy immune system and encourage healthy cognitive function.40-43

Standardized green tea extract
Green tea is packed with polyphenol compounds, the most important of which is epigallocatechin-3-gallate (ECG). Life Extension Mix's daily dose contains 325 mg of a decaffeinated green tea extract standardized to provide 98% of the active polyphenols that scientists believe are responsible for green tea's multiple health benefits. Green tea has been shown to help protect against oxidation, support healthy cellular proliferation, promote cardiovascular and metabolic health, maintain healthy DNA structure and protect nerve cells.44-62

Standardized vegetable extracts
Life Extension Mix™ offers a wide array of vegetable extracts, including a concentrated broccoli mixture with standardized extracts of sulforaphane and glucosinolates, which are believed to have detoxifying properties, promote healthy DNA and protect from oxidative stress, among many other health benefits.63-66,. A daily dose also provides 200 mg of calcium D-glucarate (supplying 175 mg of D-glucarate), a phytonutrient found in grapefruit, apples, oranges, broccoli and brussels sprouts. D-glucarate supports detoxification processes to support healthy cell proliferation.67,68

Life Extension Mix™ also contains lutein and lycopene. Lutein, an antioxidant extracted from marigold and also found in leafy greens such as kale and spinach, has been shown to help maintain critical pigments in the macula to support eye health.69 Lycopene from tomatoes helps maintain healthy DNA and cell proliferation and protect against LDL oxidation.70-73

Standardized fruit extracts
In addition to our standardized pomegranate and wild blueberry extracts, Life Extension Mix™ also features luteolin, a flavonoid shown to protect against oxidation and help inhibit inflammatory factors to support immune health.74-76 Our formula also provides fruit extracts such as bilberry, grape seed and citrus packed with potent antioxidants to promote visual acuity, healthy inflammatory response and blood circulation.77-79

Our proprietary formula is fortified with tart cherry for its antioxidant benefits for cardiovascular and brain health, as well as muscle support.80-86 It also includes a customized blend of blackberry, cranberry, plum, elderberry, persimmon, cherry and other fruits which studies indicate provide multiple favorable effects on the body.

Numerous studies have pointed toward the many benefits of olive polyphenols, and Life Extension Mix™ contains an olive extract standardized to provide polyphenols like hydroxytyrosol that have been shown to help inhibit LDL oxidation and protect against oxidative damage to support cardiovascular health.87,88

Sesame seed lignan extract
Life Extension Mix™ provides 10 mg of a sesame seed lignan extract to promote healthy levels of gamma tocopherol along with many other health-promoting properties.89-91 Sesame seed lignans also protect lipids from oxidation, help support metabolic health, help maintain already-normal cholesterol/LDL levels and enhance the beneficial effects of fish oils.92-97

Nutrients to maintain metabolic and cardiovascular health
Life Extension Mix™ contains 500 mcg of Crominex® 3+, the most advanced chromium complex, as well as highly absorbable forms of magnesium and biotin to maintain healthy glucose metabolism, beneficially impact lipid levels and promote cardiovascular health.98-106

High-potency vitamin D3
Evidence shows that many people are not supplementing with enough vitamin D, a critical nutrient for maintaining strong bone density and healthy muscle, promoting cardiovascular health and healthy glucose metabolism, boosting the immune system and more.107-110 Currently, most experts in the field believe that intakes between 1,000 and 4,000 IU for adults will lead to a healthier blood level of vitamin D; however, some individuals may require higher doses to achieve a target blood level of 50-80 ng/mL for 25-hydroxyvitamin D.111

Each daily dose of Life Extension Mix™ provides 2,000 IU of vitamin D3. What's more, this formula contains only 500 IU of preformed vitamin A. Preformed vitamin A may interfere with some of the actions of vitamin D (but this has not been shown to be the case with beta-carotene), yet most multivitamins contain between 5,000 and 25,000 IU of preformed vitamin A.

Cyanidin-3-glucoside (C3G)

Life Extension Mix™ contains 1.25 mg of C3G to support eye health. Found in blackberries and black currants, this potent compound promotes healthy levels of rhodopsin, a compound that absorbs light in the retina, and enhances night vision.112

In a clinical study, just 50 mg of a berry extract concentrate containing C3G helped aging, healthy individuals see better in the darkness after 30 minutes.113 C3G, which is highly bioavailable, also has potent antioxidant properties and supports endothelial cell health.114-117

5-MTHF (5-methyltetrahydrofolate)

Folate helps maintain homocysteine levels within the normal range, which is associated with cardiovascular health and supports cognitive function. One dose of our formula contains 400 mcg of the 5-MTHF form of folate, which is up to seven times more bioactive than ordinary folic acid.118

Selenium and Apigenin

Life Extension Mix™ contains three potent forms of selenium (SelenoExcell®, Se-methyl-selenocysteine and sodium selenite) a trace mineral with powerful antioxidant properties to support healthy cellular division, heart and brain health, as well as thyroid function.119,120

Also included is apigenin, a powerful bioflavonoid found in many vegetables and fruits, with lots of beneficial effects to protect the body from oxidative damage, promote healthy inflammatory response and help maintain already-healthy blood pressure and cell division.121-124

Super Ubiquinol CoQ10 

Coenzyme Q10 (CoQ10 for short) is a potent antioxidant that supports cardiovascular health and is absolutely essential for healthy mitochondrial function. The traditional form of CoQ10, ubiquinone, is difficult for your body to absorb — but the ubiquinol formlike that in Super Ubiquinol CoQ10 absorbs up to 8 times better!

Benefits at a Glance

Supports cardiovascular health
Promotes healthy energy production at the cellular level
Absorbs up to 8 times better than ubiquinone CoQ10
Provides powerful antioxidant support
CoQ10 and healthy mitochondria

CoQ10 is an essential component of healthy mitochondrial function.1-6 The mitochondria are the cell’s energy powerhouses, and CoQ10 is required to convert the energy unlocked from fats and sugars into usable cellular energy.

Cardiovascular health and antioxidant defense

Because of this, CoQ10 is most highly concentrated in the cells of your body’s “workhorse” organs — like your brain and your heart.7 But CoQ10 is also a potent antioxidant, protecting important proteins and mitochondrial DNA from oxidative damage.8 Unfortunately, CoQ10 levels naturally deplete over time.

Coenzyme Q10 depletion: natural and unnatural causes

CoQ10 levels in your body naturally decrease as we age. And so-called “statin” drugs used to lower cholesterol also deplete CoQ10 levels in the blood and possibly in tissue as well.9,10 Statin drugs have been shown to reduce plasma CoQ10 by nearly 40%.11 Alarmingly, the normal aging process may deplete CoQ10 levels even faster than the use of statin medications!

The aging process reduces CoQ10 levels in the heart muscle wall by 72%.12 The frightening result is that the dual effects of aging and using statin drugs simultaneously could result in a severe CoQ10 deficit, leading to seriously diminished cellular vitality in vital organs like your heart.11

Superior availability of ubiquinol CoQ10

Remember, traditional ubiquinone forms of CoQ10 are notoriously difficult for your body to absorb. And since the most important factor of any supplement is how much nutrient actually makes it into your bloodstream, you should know that scientific studies show ubiquinol CoQ10 absorbs up to 8 times greater than ubiquinone.

Clinically studied effects on aging and fatigue

In studies measuring exercise-induced fatigue, ubiquinol CoQ10 (like that in Super Ubiquinol CoQ10) was 90% more effective than ubiquinone.13 Furthermore, ubiquinol has been shown to be 40% more effective in slowing measurements of aging, compared to ubiquinone.13

Promote heart health and cellular vitality

Support your heart, promote healthy mitochondrial function, and maintain vital cellular energy production. Choose Super Ubiquinol CoQ10 — the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system with a superior absorption level.14

References
J Am Coll Nutr. 2001 Dec;20(6):591-8.
Free Radic Res. 2002 Apr;36(4):445-53.
Int J Biochem Cell Biol. 2005 Jun;37(6):1208-18.
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7.
Neurobiol Dis. 2005 Apr;18(3):618-27.
J Mol Neurosci. 2006;28(2):125-41.
Biofactors. 2003;18(1-4):91-100.
Mol Biotechnol. 2007 Sep;37(1):31-7.
Mitochondrion. 2007 Jun;7 Suppl:S168-74.
Cardiol Rev. 2005 Mar-Apr;13(2):76-9.
J Clin Pharmacol. 1993 Mar;33(3):226-9.
Biofactors. 1999;9(2-4):291-9.
Biofactors. 2008;32(1-4):119-28.
Exp Gerontol. 2006 Feb;41(2):130-40.

Vitamin B12 500 mcg, 100 lozenges

Item Catalog Number: 00361
Vitamin B12 is present in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient.232 Likewise, vitamin B12 serum concentrations are reported to be significantly lower in elderly population groups compared to younger groups.233-236 It is estimated that 10% to 30% of individuals over the age of 50 have low stomach acid secretion237,238 which results in decreased bioavailability of vitamin B12 from food. To overcome food-bound vitamin B12 malabsorption problems, the Institute of Medicine recommends that vitamin B12-fortified foods (such as fortified ready-to-eat breakfast cereals) or supplements containing vitamin B12 be used to meet much of the requirement.239 Vitamin B12, or cobalamin, works synergistically with vitamin B6 and folate to regenerate (methylate) the amino acid methionine, which helps to maintain already healthy homocysteine levels within normal range, which is important for heart health.240-243

Cyanocobalamin is a synthetic and inexpensive form of vitamin B12 that is converted in the body to its bioactive forms, methylcobalamin and cobamamide.

Optimized Chromium with Crominex® 3+

500 mcg 60 vegetarian capsules

Chromium is a critical micronutrient recognized for its vital role in maintaining healthy glucose metabolism. This most advanced chromium complex has been optimized with a standardized extract of Indian gooseberry and a proprietary form of the adaptogen shilajit. Crominex® 3+ helps support:

Normal cellular glucose absorption
Healthy endothelial function
Healthy lipid and triglyceride levels
Normal cellular energy production

Zinc Lozenges

60 vegetarian lozenges Item Catalog Number: 01561

Zinc is a mineral that stimulates the activity of approximately 300 enzymes, which are substances that promote biochemical reactions in your body.1,2 These reactions are essential for the formation of superoxide dismutase, one of the body’s most important free radical scavengers. Zinc also promotes immune function,3-6 taste sensitivity,7-9 protein and DNA synthesis,1,10,11 insulin production,12,13 reproductive organ development and sperm motility.14-16 Zinc also supports normal growth and development during pregnancy, childhood, and adolescence.17-19

Maintaining adequate levels of zinc is equally important to aging adults.20-22 As people grow older, their immune function declines, partly due to the decreasing size and function of the thymus gland. Evidence suggests that zinc may help to maintain healthy function of the thymus gland in elderly people. 23 Scientists have also found evidence that a zinc deficiency in elderly adults may contribute to impaired immune function with aging, or immunosenescence.24-26 These findings suggest that zinc plays a critical role in supporting healthy immune function with age.

Zinc Lozenges provide premium-grade zinc as gluconate and oxide in a pleasant citrus-orange naturally flavored tablet.

References
1. J Nutr. 2000 May;130(5S Suppl):1437S-46S
2. Biometals. 2005 Aug;18(4):295-303
3. Exp Gerontol. 2008 May;43(5):370-7.
4. Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L744-54.
5. Exp Gerontol. 2008 May;43(5):452-61.
6. Am J Clin Nutr. 2007 Mar;85(3):837-44
7. Acta Otolaryngol Suppl. 2002;(546):129-33.
8. Cancer. 1998 May 15;82(10):1938-45.
9. Nippon Jibiinkoka Gakkai Kaiho. 1995 Jul;98(7):1135-9.
10. J Cell Physiol. 2009 Mar;218(3):558-67.
11. Wound Repair Regen. 2007 Jan-Feb;15(1):2-16.
12. Biol Trace Elem Res. 2006 Aug;112(2):109-18.
13. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD005525.
14. Fertil Steril. 1999 Jun;71(6):1138-43.
15. Pak J Biol Sci. 2009 Jan 15;12(2):134-9.
16. Nutr Res. 2009 Feb;29(2):82-8.
17. J Trace Elem Med Biol. 2005;19(1):29-35.
18. Nutr Health. 2007;19(1-2):85-102.
19. Am J Clin Nutr. 2007 Feb;85(2):614S-620S
20. Biogerontology. 2006 Oct-Dec;7(5-6):429-35.
21. Exp Gerontol. 2008 May;43(5):493-8.
22. Rejuvenation Res. 2008 Feb;11(1):227-37.
23. Immun Ageing. 2009 Jun 12;6:9.
24. Exp Gerontol. 2008 May;43(5):452-61.
25. Nutr Rev. 2010 Jan;68(1):30-7.
26. J Nutr. 2009 Jan;139(1):113-9.

Mega Green Tea Extract

100 vegetarian capsules 
Item Catalog Number: 00953

Green tea contains health-promoting polyphenols including epigallocatechin-3-gallate (EGCG), a powerful antioxidant which has been the subject of extensive scientific research. The antioxidant activity of EGCG is about 25–100 times that of vitamins C and E.336 One cup of green tea provides roughly 100 mg of polyphenols337 and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots or strawberries.

One capsule of Life Extension’s Mega Green Tea Extract provides more polyphenols than you get from drinking seven cups of green tea. This 98% green tea extract is standardized to provide high potency EGCG, by far the most important polyphenol green tea provides. And green tea powdered extracts have been shown to absorb 60%-90% better into the bloodstream and to be far more bioavailable than drinking green tea itself.

Green tea has been shown to provide many benefits including:

Scavenging reactive oxygen species such as superoxide and the hydroxyl and peroxyl radical
Fluid-stabilizing properties
Possibly promoting weight loss
Boosting the effectiveness of enzymatic phase II detoxification
Helping maintain healthy cell proliferation
Helping maintain healthy blood cholesterol, LDL and triglyceride levels already within normal range
Enhancing immune function
Displaying protective effects on brain tissues
Mega Green Tea Extract has been concentrated and dual standardized to ensure the highest quality, consistency and biological activity. This advanced extract contains 98% total polyphenols and 45% epigallocatechin-3-gallate (EGCG).

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™
The mitochondria are the cells’ energy powerhouses, and coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function. CoQ10 is required to convert the energy from fats and sugars into usable cellular energy. Yet, the body’s production of CoQ10 declines significantly with advancing age.47 With an ample amount of CoQ10, mitochondria can work most efficiently throughout the entire body — including the most densely populated area, the heart. CoQ10 is also a potent antioxidant, helping protect proteins, and DNA of mitochondria from oxidation and supporting mitochondrial function.

More people are supplementing with CoQ10 than ever before. One reason is increased awareness that “statin” drugs used to lower LDL and cholesterol deplete CoQ10 levels in the blood, and possibly the tissues. What most doctors don’t know, however, is that normal aging may result in more of a reduction in CoQ10 than taking statins. For example, while statin drugs have been shown to reduce plasma CoQ10 by nearly 40%,51 the aging process reduces CoQ10 levels in the heart muscle wall by 72%. What is particularly frightening is the deficit caused by the dual effects of aging53 and statin drug use that can result in severe depletion of cellular vitality.

CoQ10 is notoriously difficult to absorb. When it comes to choosing a CoQ10 supplement, the primary factor is how many swallowed milligrams actually make it into your bloodstream.

Scientific studies show that ubiquinol absorbs up to 8 times greater than ubiquinone, and higher levels of ubiquinol remain in the blood far longer than ubiquinone. In studies measuring exercise-induced fatigue, ubiquinol was 90% more effective than ubiquinone. In middle-aged mice, ubiquinol was shown to be 40% more effective in slowing measurements of aging compared to ubiquinone. Life Extension offers the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system with a superior absorption level. This formulation contains an ingredient called PrimaVie® shilajit that research shows doubles levels of CoQ10 in mitochondria. Shilajit has been shown to help restore and sustain cellular energy. The latest studies reveal that when shilajit is combined with CoQ10, cellular energy gains substantially increase.

In a breakthrough preliminary study in mice, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain — 40% better than CoQ10 alone. In muscle there was a 144% increase, or 27% better than CoQ10 alone.

Researchers have found that shilajit works to boost CoQ10’s beneficial effects by:

• Stabilizing CoQ10 in its superior ubiquinol form, thereby prolonging its action at the cellular level.
• Facilitating more efficient delivery of CoQ10 into the mitochondria, resulting in greater cellular energy output.
• Scientific analysis shows that shilajit itself is rich in essential compounds that promote mitochondrial metabolism. Part of shilajit’s beneficial effects derive from its ability to help the mitochondria convert fats and sugars into adenosine triphosphate, or ATP, the main source of cellular energy.

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ combines super absorbable ubiquinol CoQ10 with shilajit to generate a powerful synergy that supports more youthful cellular energy production than CoQ10 alone.

References ​

Sea-Iodine™
1000 mcg, 60 vegetarian capsules
Item Catalog Number: 01740

For decades, Americans have been told to avoid table salt to reduce their risk of hypertension and related health conditions. But when iodized table salt is reduced, people can unknowingly lower their iodine intake to suboptimal levels. Analyses from the National Health and Nutrition Examination Survey (NHANES) show that urinary iodine levels have plummeted since the 1970s.

Energy Renew (30)
Reduce general fatigue and maintain energy levels

• Maintain energy levels
• Support vital body activities affected by energy metabolism
• Minimize fatigue-related decline associated with aging

Common complaints about fatigue include low energy, unrefreshed sleep, head or muscle discomfort and weakness. Stimulants such as caffeine offer only short-term relief with possible health consequences.

RiboGen™, a proprietary extract of the French oak tree (Quercus robur), provides unique bioactive polyphenol compounds called roburins. Evidence suggests that roburins support ribosomes, which are the small molecular factories in the cell that create proteins in the body.

Oak wood extract is now being hailed for its ability to support ribosomal biogenesis, the body’s natural way of restoring ailing ribosomes. Researchers found that a regimen with oak wood extract upregulated important genes involved in ribosomal biogenesis.

In a human study, researchers found that RiboGen™ provided the following benefits:

18% reduction in weakness and exhaustion.
44% reduction in unrefreshing sleep.
33% reduction in head discomfort.
51% reduction in joint discomfort.
63% reduction in muscle discomfort.
RiboGen™ French Oak Wood Extract

This product is the ideal option for those who would like to target complaints of general fatigue at the subcellular level throughout the body, including:

Roburins And Chronic Fatigue
The clinical impact of roburin-rich oak wood extract was made evident by a second important human study, this one conducted among patients with known chronic fatigue syndrome. In the study, adults with at least five primary chronic fatigue syndrome symptoms were treated with 200 mg/day of Robuvit® oak wood extract for a minimum of six months.3 A control group that did not use the supplement was also established among patients with the same chronic fatigue symptoms. The scientists found that oak wood extract was productive in alleviating many of the most troubling symptoms of chronic fatigue.

Among those who used the oak wood extract, there were significant reductions for a multitude of key symptoms of chronic fatigue, including:

18% reduction in weakness and exhaustion,
44% reduction in unrefreshing sleep,
29% reduction in short-term memory impairment,
63% reduction in muscle pain,
51% reduction in joint pain,
33% reduction in headaches, and
47% reduction in tender lymph nodes in the armpit and neck.3
Additionally, impressive reductions from baseline were also found in most secondary symptoms of chronic fatigue syndrome, including:

51% reduction in sensitivity to noise, foods, medications, and chemicals,
38% reduction in dizziness,
58% reduction in depression,
49% reduction in mood swings,
40% reduction in weight fluctuation,
24% reduction in alcohol intolerance,
39% reduction in allergies, and
29% reduction in visual disturbances.
There were no significant changes from baseline in all of these parameters for the patient group not taking the oak wood extract