Enhanced Vitality and Health: A Pivotal Human Trial on NMN Supplementation
Research consensus indicates that high NAD levels in humans are beneficial, promoting longevity and aiding disease prevention. Hence, anti-aging researchers continually explore strategies to elevate NAD levels as we age.
Nicotinamide Mononucleotide (NMN) supplementation, a natural molecule that our bodies convert into NAD, may be one such method. Numerous studies correlate NMN intake with increased NAD levels, though correlation doesn't guarantee causation.
Only animal studies confirmed NMN supplementation's effect on boosting NAD concentrations until this game-changing human trial.
An international research team tested NMN supplementation's efficacy and safety in a human clinical trial, published in the GeroScience Journal in December 2022. The comprehensive, multi-goal study investigated how different NMN dosages influenced NAD concentrations, NMN's tolerability and safety, and its clinical efficacy using various assessments.
The gold-standard randomized, double-blind, placebo-controlled, dose-dependent trial involved 80 middle-aged (40-65 years) healthy adults. They were divided into three experimental groups and a placebo control group, each supplementing 300, 600, or 900 mg of NMN orally daily.
This 60-day trial involved rigorous assessments, including safety and tolerability checks, NAD concentration measurement, endurance testing, "biological age" calculation, insulin resistance assessment, and quality of life evaluations.
The results indicated that NMN supplementation is safe and relatively tolerable with significant NAD concentration elevation. NMN also improved physical endurance, reduced "biological age," and enhanced participants' perceived quality of life and general health.
Interestingly, the trial showed that a daily dosage of 600 mg provided significant improvements over 300 mg, but increasing the dosage to 900 mg offered no additional benefits. This study suggests that daily NMN supplementation can positively impact general health, well-being, aging, and endurance.
Generally about NMN
NMN (nicotinamide mononucleotide), a naturally produced molecule and NAD precursor, offers multiple health benefits, particularly in aging and longevity. Consuming NMN supplements, available as powder or capsules, can potentially elevate NAD levels, leading to health improvements.
Key health benefits of NMN supplementation include:
- Enhanced energy metabolism and physical endurance, counteracting age-related energy decline.
- Boosted brain health and memory, fostering brain cell protection and better cognitive function while mitigating neurodegenerative diseases.
- Improved heart health, entailing blood pressure regulation, improved cholesterol levels, and clot prevention to reduce cardiovascular disease risks.
- Positive impacts on diabetes and obesity, through better insulin sensitivity, blood sugar control, and reduction in inflammation and oxidative stress.
- Skin rejuvenation, diminishing aging signs like wrinkles and sagging via collagen production and hydration enhancement.
- Strengthened immune system, bolstering resistance to bacterial, viral, or fungal infections.
- Improved eye function, shielding eyes from aging and light exposure damage, thereby enhancing vision quality.
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