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Researchers and physicians all over the globe are singing the praises of GSH — loud and long. And, it’s no wonder. Every cell in the body needs GSH and most actually make it. They have also determined that physical and emotional stress, pathogens, toxins, free-radicals and aging produce GSH deficiencies. Now, research confirms that boosting blood and intracellular levels of GSH provides a myriad of health-protecting and heath-promoting benefits for the brain, the heart, blood, eyes, liver, kidneys, pancreas, joints and overall energy levels.* Because normal GSH is destroyed in the stomach, until now, one could only boost GSH levels with expensive and hard to get GSH injections or glutathione precursors that the body may or may not use to create GSH. Now, that problem is solved... Lypo-Spheric™ GSH — the easiest, surest way to boost GSH levels. LivOn’s “Smart Lyposomal Nano-Spheres®” transport GSH through the digestive system and into the bloodstream completely unscathed. From there it is even carried into individual cells — intact and ready to: * neutralize free-radicals and help repair the damage they do* * help neutralize and eliminate toxins and heavy metals (like cadmium, lead and mercury)* * help fuel and energize the immune system* * support transport of amino acids across cell membranes* * help promote repair and synthesizing of DNA* There are two other difficulties solved by delivering intact GSH directly into the blood with the aid of LET. First, because the three amino acid precursors necessary for GSH synthesis are also needed throughout the body for other purposes – there is no guarantee that the body will not soak them up for other purposes. Secondly, since it is impossible to know how much GSH the body will make from the surviving precursors, consistent dosing is difficult to impossible. With Lypo-Spheric™ GSH you know you are ingesting 450 mg of reduced (the active form) glutathione sulfhydryl that will be delivered intact to the bloodstream and available for immediate action wherever your body may need it.* Fact: there’s no better way to supplement with GSH! Dosage and Use As a dietary supplement, take one to two packets per day for boosting the immune system and maintaining cardiovascular, hepatic and glandular health. For best results, snip or tear the notched end off the packet, squeeze into your favorite cool beverage and drink on an empty stomach. We do not recommend mixing the product with a hot beverage or with any high-speed blenders or food processors. Storage Instructions Store in a cool, dry place. Do not freeze or place the product in direct sunlight for extended periods of time. Shelf Life When stored properly, the Altrient Lypo-Spheric™ GSH will stay 100% effective for a minimum of 4 months from the time of purchase. The expiration date is on the bottom of each carton and on each packet as “XMMYR”.
So what are liposomes, exactly?
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| Representation of a phospholipid molecule showing phosphate head (orange), the glycerol sholders (blue) and the fatty acid tails (silver) |
Liposomes are bilayer (double-layer), liquid-filled bubbles made from phospholipids. Over 50 years ago, researchers discovered that these spheres could be filled with therapeutic agents and used to protect and deliver these agents into the body and even into specific cells of the body.
The bilayer structure of liposomes is nearly identical to the bilayer construction of the cell membranes that surround each of the cells in the human body. This occurs because of the unique composition of phospholipids. The phosphate (source of "phospho" in phospholipid) head of phospholipids is hydrophilic — it loves water — whereas the fatty-acid tails (lipids) are hydrophobic — they hate water.
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| Liposome containing vitamin C. Currently liposome-encapsulation is the best oral way to deliver vitamin C known to man. |
When phospholipids find themselves in a water-based solution, the hydrophobic tails quickly move to distance themselves from the liquid just like oil separates from vinegar. So, as all the tails turn inward and all the heads turn toward the liquid, they form a double-layered membrane.
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| This diagram of a liposome cutaway shows how the tails of phospholipids turn inward to form a bilayer membrane, and encapsulate a therapeutic agent. |
Although research has not clearly shown how the therapeutic agents in a liposome are actually released, there are a couple of theories. One theory suggests that the phospholipids are processed in the liver as fats and that this process releases the vitamin C. Another theory proposes that cells all over the body, hungry for phospholipid materials to repair cell membranes and other cellular structures, "steal" these materials from the liposome allowing their contents to leak out.
Quite possibly both processes occur. In any case, the therapeutic value and greatly increased delivery of liposome-encapsulated drugs and nutrients has been scientifically confirmed countless times. At present, liposomes are the most effective oral way to deliver nutrients.
Phospholipids are the primary building blocks of cellular membranes. These membranes are the "containers" that hold the living matter within each cell. They also give definition, shape, and protection to many of the substructures (organelles within the cell like the nucleus and mitochondria) within our cells.
In addition to functioning as a skin for each cell — keeping the insides in and the outsides out — phospholipid membranes provide protection from chemicals and pathogens that can derail and/or destroy the necessary life functions that take place within each cell. While performing this function, phospholipid membranes are subject to constant attack from free radicals (oxidants), pathogens, and toxins.
In order to repair the structural damage caused by the continual barrage of toxic substances and pathogens, your body requires a constant supply of phospholipids. The body can synthesize some phospholipid compounds but others must be supplied by the diet. Phospholipids that can only be obtained through dietary intake are called "essential phospholipids."
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| Anatomy of a phosphatidylcholine molecule. All phospholipids have a phosphate group and fatty acid chains connected by a glycerol group. Phosphatidylcholine, a class of essential phospholipids, has two distinguishing characteristics: 1) a choline head and 2) one of the fatty acid chains is an omega-6 fatty acid. (KEY — Gray: carbon atoms; Teal: hydrogen atoms; Blue: oxygen atoms; Violet: phosphorus atom; Gold: nitrogen atom.) |
At the basic level, phospholipids are a phosphate group (phospho) attached to fatty acids (lipids) by means of a glycerol group.
Unlike phosphates, which are attracted to water (hydrophilic), fatty acids are repelled by water (hydrophobic). It is this very love/hate relationship with water that allows phospholipids to form cellular membranes — and liposomes as well.
As phospholipids are exposed to water-based solutions, they automatically align themselves in a double-layer (bilayer) configuration - phosphates toward the water and fatty acids away from the water.
One of the most important and prominent phospholipids in cell membranes is called phosphatidylcholine (PC) [pronounced FOSS-fah-tide-al-KOH-lean]. At birth up to 90% of cellular membranes are made up of PC. As humans age, the percentage of PC in their cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid.
Intact PC — as well as its essential fatty acid and choline components — is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function.
The liposomes used for Lypo-Spheric™ supplements made from essential phospholipids that include a high percentage of Phosphatidylcholine. These liposomes not only provide optimum protection and superior transport for the Lypo-Spheric™ nutrients, they also help satisfy the body's need for PC, omega-6 fatty acids, and choline.
Dr. Thomas E. Levy, board certified cardiologist and world renown vitamin C expert, on ihealthtube.com
A Farmer, A Body Builder and A Prize Winning Cocker Spaniel...
What could a New Zealand Farmer, a Body Builder and a Cocker Spaniel named Maggie all have in common? Vitamin C is the common denominator. Of course this is a special Vitamin C... Lypo-Spheric Vitamin C based on a...
Liposome Science Articles
Essential phospholipids: What they are
Without these amazing molecules your body would be a puddle of messy goo...
The importance of bioavailability
failure to understand bioavailability often results in taking too much or too little of a supplement...
What are liposomes, exactly?
These little bubbles accomplish "miraculous" things...
Studies and Resources
References/Citations/Summaries
Gropper SS, Smith JL, Groff JL, (2009), Advanced Nutrition and Human Metabolism, West Publishing Co. p 313.
Vitamin C [non-liposomal] bioavailability decreases with dose size
As dose size increases, bioavailabiity decreases dramatically. The authors express this finding by stating that 98% of a 20 mg oral dose of [non-liposome-encapsulated] vitamin C is bioavailable (enters the bloodstream) whereas only 16% of a 12,000 mg dose does so.
Gerster H, (1987), Human vitamin C requirements, Z Ernahrungswiss. Jun;26(2):125-37.
Bioavailability of [non-liposome-encapsulated] vitamin C
Based on previous recommended daily allowance (RDA) studies by the National Institutes of Health, author suggests that a 200 mg daily intake of vitamin C is sufficient to provide tissue saturation. By implication, any additional vitamin C would not be used or bioavailable. He does also suggest that smokers and those in disease states may have a higher requirement for vitamin C. [NOTE: Hickey & Roberts (2004) debunk the flawed nature of these NIH studies]
Hickey S., Roberts H, Miller N, (2008), "Pharmacokinetics of oral vitamin C" Journal of Nutritional & Environmental Medicine July 31.
Liposome-encapsulated vitamin C dramatically increases blood levels
Authors found that a liposome-encapsulated vitamin C nearly doubled bioavailability over that thought possible from studies published by the National Institutes of Health.
Hickey S, Roberts H, (2004), Ascorbate: The Science of Vitamin C, 2004.
Ascorbate: The Science of Vitamin C
This book presents a new model, describing the action of vitamin C in health. It demonstrates conclusively that the establishment has misinterpreted the evidence. The dynamic flow model explains the current results and points the way for future experiments. This book is a must for people who want to understand the scientific evidence and support for high-dose vitamin C.
Kelly C, Jefferies C, Cryan SA, (2011), "Targeted liposomal drug delivery to monocytes and macrophages," J Drug Deliv.
Liposomes used to deliver drugs to specifically targeted cells
Liposomes can be used to effectively deliver therapeutic agents particular cell types (mononuclear phagocytic system, particularly macrophages). These cells are of particular importance in the immune system.
Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. (1996), "Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance," Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9..
Bioavailability of (non-liposomal) vitamin C decreases rapidly with dose size
Authors report very rapid decline in bioavailability [of non-liposome-encapsulated vitamin C] with dose size. The "steep portion of the curve" starts between 30 mg and 100 mg of daily dose. Based on their findings, they suggest that "vitamin C daily doses above 400 mg have no evident value." This conclusion is based on the faulty presupposition that the appearance of vitamin C in the urine indicates all bodily tissues are saturated and the body requires no additional vitamin C. This assumption is clearly refuted by Hickey, et al. in his bookAscorbate: The Science of Vitamin C referenced above.
Mitsopoulos P, Suntres ZE, (2011), "Protective Effects of Liposomal N-Acetylcysteine against Paraquat-Induced Cytotoxicity and Gene Expression," J Toxicol.
Liposomal encapsulation improves delivery of therapeutic agent
N-acetylcysteine (NAC) was encapsulated in liposomes and administered as a trea™ent for paraquat poisoning. Pretrea™ent with this liposomal NAC was found to be more effective than conventional drugs in reducing the effects of paraquat poisoning.
Parmentier J, Thewes B, Gropp F, Fricker G, (2011), "Oral peptide delivery by tetraether lipid liposomes," Int J Pharm. Jun 2.
Liposome encapsulation improves peptide bioavailability
Liposomes were used to deliver peptides agents which normally break down in the stomach. Bioavailability in some tests improved by 460%.
Additional Information
| manufacturer | Livonlabs |
|---|---|
| Tax Class | Momspliktige varer 15% |
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